Article
p53 gene mutations in gastric and esophageal cancers.
Gastroenterology - 1 Sept 1992
Imazeki F, Omata M, Nose H, Ohto M, Isono K
Abstract excerpt
The presence of point mutation of the p53 gene in exons 5, 6, 7, and 8 was examined in 10 cases of gastric adenocarcinoma and 5 cases of esophageal squamous cell carcinoma by polymerase chain reaction and direct nucleotide sequencing. Mutations of the p53 gene were found in 5 cases of gastric cancer and 4 cases of esophageal cancer. The mutations in the stomach cancers consisted of four missence mutations (exons...
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