Article
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Biochemical and biophysical research communications - 15 Jan 1992
Matozaki T, Sakamoto C, Matsuda K, Suzuki T, Konda Y, Nakano O, Wada K, Uchida T, Nishisaki H, Nagao M
Abstract excerpt
To investigate the molecular pathogenesis of human gastric cancers the p53 gene, a suppressor oncogene, was analyzed in 12 human gastric cell lines. Southern blot and Northern blot analysis revealed a total deletion of p53 gene in KATO-III cells but no major abnormality of p53 gene in other cell...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cell Line
- Chromosome Deletion
- Codon
- DNA, Neoplasm
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- RNA, Neoplasm
- RNA-Directed DNA Polymerase
- Stomach Neoplasms