Article
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Apr 2011
Chen Han-Chun, Chen Hui-Juan, Khan Md Asaduzzaman, Rao Zhou-Zhou, Wan Xin-Xing, Tan Bo, Zhang Dian-Zheng
Abstract excerpt
This case-control study investigated the mutations in p53 and k-ras genes of 123 gastric carcinoma patients and 129 normal individuals from Hunan, China. By isolating genomic DNA from peripheral blood and employing polymerase chain reaction-single strand conformation polymorphism and DNA sequencing, the mutations of p53 exons-5, 6, 7, and 8 and k-ras were detected. The overall mutation frequency of p53 was 29.3%,...
Topics
- Adult
- Aged
- Alleles
- Case-Control Studies
- China
- Codon
- Exons
- Female
- Frameshift Mutation
- Genes, p53
- Genes, ras
- Humans
- Male
- Middle Aged
- Point Mutation
- Stomach Neoplasms