Article
Alterations of p53 gene in primary gastric cancer tissues.
Anticancer research - 1 Jan 2000
Hong S I, Hong W S, Jang J J, Lee D S, Cho N S, Jung M E, Kim H B, Ha G W, Park I C, Cho D S
Abstract excerpt
This study was conducted to investigate the p53 gene alterations in 25 surgically-resected gastric adenocarcinomas in the Korea Cancer Center Hospital by polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP) for exons 4-8 and immunohistochemical staining (IHCS) with anti-p53 antibody, DO-7. p53 mutations were detected in nine (36%) out of 25 cancer tissues by PCR-SSCP in exon 4-8:...
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