Molecular Basis of Hepatitis C Virus–Associated Hepatocarcinogenesis: Lessons From Animal Model Studies

Abstract excerpt

Despite numerous lines of epidemiologic evidence connecting HCV infection and the development of hepatocellular carcinoma (HCC), it remains controversial whether HCV itself plays a direct role or an indirect role in the pathogenesis of HCC. Through the use of transgenic mice, it has become evident that the core protein of HCV has oncogenic potential. HCV is directly involved in hepatocarcinogenesis, albeit other...

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