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HCV Activates Somatic L1 Retrotransposition—A Potential Hepatocarcinogenesis Pathway

11 Oct 2021

Abstract excerpt

Hepatitis C virus (HCV) is a common cause of hepatocellular carcinoma (HCC). The activation and mutagenic consequences of L1 retrotransposons in virus-associated-HCC have been documented. However, the direct influence of HCV upon L1 elements is unclear, and is the focus of the present study. L1 transcript expression was evaluated in a publicly available liver tissue RNA-seq dataset from patients with chronic HCV...

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PMID: 34680227
DOI: 10.3390/cancers13205079

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