Article
Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection.
The American journal of pathology - 1 Dec 1999
Huang H, Fujii H, Sankila A, Mahler-Araujo B M, Matsuda M, Cathomas G, Ohgaki H
Abstract excerpt
Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide. Hepatitis B virus and hepatitis C virus infections, exposure to aflatoxin, and excessive intake of alcohol have been identified as major risk factors. However, the molecular mechanisms underlying their development are still poorly understood. Recently, beta-catenin, one of the key components of the Wnt signaling pathway, has been...
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