Hepatitis B virus: molecular virology and common mutants.

doi:10.1055/s-2006-939754

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Article

Hepatitis B virus: molecular virology and common mutants.

Seminars in liver disease - 1 May 2006

Harrison Tim J

Abstract excerpt

A high rate of viral turnover, combined with an error-prone polymerase, results in a very high frequency of mutational events during hepatitis B virus replication. Mutants may accumulate, particularly in individuals at advanced stages of persistent infection and with antibody- and cell-mediated immune responses to the virus. Specific mutants may be selected from these populations, especially by antibody and...

Topics

Hepatitis B
Hepatitis B Core Antigens
Hepatitis B virus
Humans
Mutation
RNA, Viral
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 16673287
DOI: 10.1055/s-2006-939754

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