Article
Hepatitis B virus: molecular virology and common mutants.
Seminars in liver disease - 1 May 2006
Harrison Tim J
Abstract excerpt
A high rate of viral turnover, combined with an error-prone polymerase, results in a very high frequency of mutational events during hepatitis B virus replication. Mutants may accumulate, particularly in individuals at advanced stages of persistent infection and with antibody- and cell-mediated immune responses to the virus. Specific mutants may be selected from these populations, especially by antibody and...
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