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Article

B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes.

Journal of virology - 1 Mar 2013

Tucci Felicia Anna, Broering Ruth, Johansson Patricia, Schlaak Joerg F, Küppers Ralf

Abstract excerpt

Hepatitis C virus (HCV) is considered to have a causative role in B-cell lymphoproliferative diseases, including B-cell lymphomas, in chronic virus carriers. Previous data from in vitro HCV-infected B-cell lines and peripheral blood mononuclear cells from HCV-positive individuals suggested that HCV might have a direct mutagenic effect on B cells, inducing mutations in the tumor suppressor gene TP53 and the...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis C, Chronic

Share to Lymphoma, B-Cell

Share to Proto-Oncogene Proteins c-bcl-6

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Source

Open in PubMed Open full text

Identifiers

PMID: 23269799
DOI: 10.1128/JVI.03081-12
PMCID: PMC3571368

Genes

BCL6
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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