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Article

Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes.

Journal of virology - 1 Aug 2004

Machida Keigo, Cheng Kevin T-H, Sung Vicky M-H, Lee Ki Jeong, Levine Alexandra M, Lai Michael M C

Abstract excerpt

Hepatitis C virus (HCV) infection causes hepatitis, hepatocellular carcinoma, and B-cell lymphomas in a significant number of patients. Previously we have shown that HCV infection causes double-stranded DNA breaks and enhances the mutation frequency of cellular genes, including proto-oncogenes an...

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Identifiers

PMID: 15280491
DOI: 10.1128/JVI.78.16.8835-8843.2004
PMCID: PMC479064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15280491-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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