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Tumor Suppressors, Chromosomal Instability, and Hepatitis C Virus–Associated Liver Cancer

17 Oct 2008

Abstract excerpt

Hepatitis C virus (HCV) is the only known RNA virus with an exclusively cytoplasmic life cycle that is associated with cancer. The mechanisms by which it causes cancer are unclear, but chronic immune-mediated inflammation and associated oxidative chromosomal DNA damage probably play a role. Compelling data suggest that the path to hepatocellular carcinoma in chronic hepatitis C shares some important features with...

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PMID: 18928409
DOI: 10.1146/annurev.pathol.4.110807.092202

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