Article
Common variants of ACE contribute to variable age-at-onset of Alzheimer's disease.
Human genetics - 1 Apr 2004
Kehoe Patrick G, Katzov Hagit, Andreasen Niels, Gatz Maragaret, Wilcock Gordon K, Cairns Nigel J, Palmgren Juni, de Faire Ulf, Brookes Anthony J, Pedersen Nancy L, Blennow Kaj, Prince Jonathan A
Abstract excerpt
Studies on the role that genetic variation may play in a complex human disease can be empowered by an assessment of both disease risk in case-control or family models and of quantitative traits that reflect elements of disease etiology. An excellent example of this can be found for the epsilon4 allele of APOE in relation to Alzheimer's disease (AD) for which association with both risk and age-at-onset (AAO) is...
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