Article
Targeting Neuroplasticity, Cardiovascular, and Cognitive-Associated Genomic Variants in Familial Alzheimer's Disease.
Molecular neurobiology - 1 May 2019
Vélez Jorge I, Lopera Francisco, Creagh Penelope K, Piñeros Laura B, Das Debjani, Cervantes-Henríquez Martha L, Acosta-López Johan E, Isaza-Ruget Mario A, Espinosa Lady G, Easteal Simon, Quintero Gustavo A, Silva Claudia Tamar, Mastronardi Claudio A, Arcos-Burgos Mauricio
Abstract excerpt
The identification of novel genetic variants contributing to the widespread in the age of onset (AOO) of Alzheimer's disease (AD) could aid in the prognosis and/or development of new therapeutic strategies focused on early interventions. We recruited 78 individuals with AD from the Paisa genetic isolate in Antioquia, Colombia. These individuals belong to the world largest multigenerational and extended pedigree...
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