Article
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
American journal of human genetics - 1 Nov 2008
Bertram Lars, Lange Christoph, Mullin Kristina, Parkinson Michele, Hsiao Monica, Hogan Meghan F, Schjeide Brit M M, Hooli Basavaraj, Divito Jason, Ionita Iuliana, Jiang Hongyu, Laird Nan, Moscarillo Thomas, Ohlsen Kari L, Elliott Kathryn, Wang Xin, Hu-Lince Diane, Ryder Marie, Murphy Amy, Wagner Steven L, Blacker Deborah, Becker K David, Tanzi Rudolph E
Abstract excerpt
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four genes have been established to either cause early-onset autosomal-dominant AD (APP, PSEN1, and PSEN2(1-4)) or to increase susceptibility for late-onset AD (APOE5). However, the heritability of late-onset AD...
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