Article
Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years.
Alzheimer disease and associated disorders - 1 Mar 1998
Breitner J C, Jarvik G P, Plassman B L, Saunders A M, Welsh K A
Abstract excerpt
The epsilon4 allele at APOE, the polymorphic locus for apolipoprotein E, increases the risk of Alzheimer disease (AD), especially among those with the homozygous epsilon4/epsilon4 genotype. In family studies, epsilon4 homozygotes typically develop AD at 55-75 years, an age range when AD is otherw...
Topics
- Age of Onset
- Aged
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Epidemiologic Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Registries
- Risk Factors
- Twins