Article
Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years.
Alzheimer disease and associated disorders - 1 Mar 1998
Breitner J C, Jarvik G P, Plassman B L, Saunders A M, Welsh K A
Abstract excerpt
The epsilon4 allele at APOE, the polymorphic locus for apolipoprotein E, increases the risk of Alzheimer disease (AD), especially among those with the homozygous epsilon4/epsilon4 genotype. In family studies, epsilon4 homozygotes typically develop AD at 55-75 years, an age range when AD is otherwise relatively infrequent. Population-based studies of the AD risk associated with allele epsilon4 (and especially with...
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