Article
Apolipoprotein E alleles as risk factors in Alzheimer's disease.
Annual review of medicine - 1 Jan 1996
Roses A D
Abstract excerpt
Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset diseases, the genetic etiologies have been well identified. Three early onset forms of AD inherited as autosomal dominant traits account for less than 2% of prevalent AD. A major susceptibility locus, apolipoprotein E (APOE, gene; apoE, protein) is...
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