Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.

Abstract excerpt

Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the elderly. Predominantly this disease is sporadic in nature with only a small percentage of patients exhibiting a familial trait. Early-onset AD may be explained by single gene defects; however, most AD cases are late onset (> 65 years) and, although there is no known definite cause for this form of the disease, there are several known...

Topics

• Alzheimer Disease
• Animals
• Apolipoproteins E
• Gene Expression Regulation
• Genetic Predisposition to Disease
• Humans
• Polymorphism, Genetic
• Promoter Regions, Genetic
• Risk
• Risk Factors
• Transcription, Genetic