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Article

Genome-wide association analysis of age-at-onset in Alzheimer's disease.

Molecular psychiatry - 1 Dec 2012

Kamboh M I, Barmada M M, Demirci F Y, Minster R L, Carrasquillo M M, Pankratz V S, Younkin S G, Saykin A J, Sweet R A, Feingold E, DeKosky S T, Lopez O L

Abstract excerpt

The risk of Alzheimer's disease (AD) is strongly determined by genetic factors and recent genome-wide association studies (GWAS) have identified several genes for the disease risk. In addition to the disease risk, age-at-onset (AAO) of AD has also strong genetic component with an estimated heritability of 42%. Identification of AAO genes may help to understand the biological mechanisms that regulate the onset of...

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Source

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Identifiers

PMID: 22005931
DOI: 10.1038/mp.2011.135
PMCID: PMC3262952

Genes

APOE
DCHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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