Article
An age effect on the association of common variants of ACE with Alzheimer's disease.
Neuroscience letters - 18 Sept 2009
Helbecque Nicole, Codron Valerie, Cottel Dominique, Amouyel Philippe
Abstract excerpt
It is now well established that vascular risk factors are associated with cognitive performances. The renin-angiotensin system (RAS) components, major determinants of the cardiovascular system, are expressed in the brain and were shown to play a role on amyloid metabolism, learning and memory. The angiotensin-converting enzyme (ACE), a pivotal RAS protein, is encoded by a huge gene containing many variants, one...
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