Article
Haplotypes extending across ACE are associated with Alzheimer's disease.
Human molecular genetics - 15 Apr 2003
Kehoe Patrick G, Katzov Hagit, Feuk Lars, Bennet Anna M, Johansson Boo, Wiman Björn, de Faire Ulf, Cairns Nigel J, Wilcock Gordon K, Brookes Anthony J, Blennow Kaj, Prince Jonathan A
Abstract excerpt
Numerous genes have been implicated in Alzheimer's disease (AD), but, with the exception of a demonstrated association with the epsilon 4 allele of APOE, findings have not been consistently replicated across populations. One of the most widely studied is the gene for angiotensin I converting enzyme (ACE ). A meta-analysis of published data on a common Alu indel polymorphism in ACE was performed which indicated...
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