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Article

Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Mar 2004

Rebbeck Timothy R, Friebel Tara, Lynch Henry T, Neuhausen Susan L, van 't Veer Laura, Garber Judy E, Evans Gareth R, Narod Steven A, Isaacs Claudine, Matloff Ellen, Daly Mary B, Olopade Olufunmilayo I, Weber Barbara L

Abstract excerpt

PURPOSE: Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the clinical use of this risk-management strategy. Thus, we estimated the degree of breast cancer risk reduction after surgery in women who carry these mutations. PATIENTS AND METHODS: Four hundred eighty-three women with disease-associated...

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Identifiers

PMID: 14981104
DOI: 10.1200/JCO.2004.04.188

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group.PMID 14981104Read ↗

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