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Article

Does bilateral mastectomy affect clinical outcomes in BRCA1/2 mutation carriers with primary breast cancer? A systematic review and meta-analysis.

Familial cancer - 16 Feb 2026

de Souza Wagner Pedro Henrique, Freitas Uchôa Matheus Gustavo Tadeu, Zimermann Kamitani Hideki, Azevedo de Carvalho Pedro Lucas, de Moraes Francisco Cezar Aquino

Abstract excerpt

BACKGROUND: BRCA1/2-carriers—who account for 5–10% of breast cancer (BC) cases—face markedly elevated lifetime risks of BC. Among those diagnosed with primary breast cancer (PBC), these carriers confront a cumulative contralateral breast cancer (CBC) risk of 40% within 10 years—alongside poorer overall survival (OS) and breast cancer–specific survival (BCSS). Whether contralateral risk-reducing mastectomy (CRRM)...

Topics

Female
Humans
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Genes, BRCA1
Genes, BRCA2
Heterozygote
Mastectomy
Mutation
Prophylactic Mastectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41697510
DOI: 10.1007/s10689-026-00535-6

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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