Article
Risk reduction and survival benefit of prophylactic surgery in BRCA mutation carriers, a systematic review.
American journal of surgery - 1 Oct 2016
Ludwig Kandice K, Neuner Joan, Butler Annabelle, Geurts Jennifer L, Kong Amanda L
Abstract excerpt
BACKGROUND: Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may be faced with questions about surgical risk reduction and survival benefit of prophylactic surgery. METHODS: A systematic literature review was performed using the electronic databases PubMed, OVID MEDLINE, and Scopus comparing...
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