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Article

Effectiveness of Prophylactic Surgeries in BRCA1 or BRCA2 Mutation Carriers: A Meta-analysis and Systematic Review.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2016

Li Xiao, You Ran, Wang Xinwei, Liu Congxin, Xu Zicheng, Zhou Jin, Yu Bin, Xu Ting, Cai Hongzhou, Zou Qing

Abstract excerpt

PURPOSE: To systematically investigate the effectiveness of prophylactic surgeries (PS) implemented in women carrying BRCA1/2 mutations. EXPERIMENTAL DESIGN: The PubMed database was searched till August 2014 and 15 studies met the inclusion criteria. Fixed- or random-effects models were conducted according to study heterogeneity. We calculated the pooled relative risks (RR) for cancer risk or mortality along with...

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Source

Identifiers

PMID: 26979395
DOI: 10.1158/1078-0432.CCR-15-1465

Genes

BRCA1
BRCA2
CPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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