Differences Among a Modern Cohort of BRCA Mutation Carriers Choosing Bilateral Prophylactic Mastectomies Compared to Breast Surveillance.

doi:10.1245/s10434-017-5976-2

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Article

Differences Among a Modern Cohort of BRCA Mutation Carriers Choosing Bilateral Prophylactic Mastectomies Compared to Breast Surveillance.

Annals of surgical oncology - 1 Oct 2017

Gilbert Elizabeth, Zabor Emily C, Stempel Michelle, Mangino Debra, Heerdt Alexandra, Pilewskie Melissa

Abstract excerpt

BACKGROUND: Women with a BRCA mutation have significantly elevated breast cancer risk, which can be reduced by >90% with bilateral prophylactic mastectomy (BPM). We sought to compare a cohort of BRCA mutation carriers choosing BPM versus breast surveillance to better elucidate factors that may impact decision making. METHODS: Women with a BRCA mutation were retrospectively identified from a prospectively...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
BRCA1 Protein
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Lobular
Early Detection of Cancer
Female
Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Middle Aged

Mutation

Neoplasm Invasiveness

Prognosis

Prophylactic Mastectomy

Source

Open in PubMed Open full text

Identifiers

PMID: 28766223
DOI: 10.1245/s10434-017-5976-2
PMCID: PMC5802967

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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