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Article

Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers.

Journal of the National Cancer Institute - 1 Sept 1999

Rebbeck T R, Levin A M, Eisen A, Snyder C, Watson P, Cannon-Albright L, Isaacs C, Olopade O, Garber J E, Godwin A K, Daly M B, Narod S A, Neuhausen S L, Lynch H T, Weber B L

Abstract excerpt

BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1 gene provides potentially valuable information to women at high risk of breast or ovarian cancer; however, carriers of BRCA1 mutations have few clinical management options to reduce their cancer risk. Decreases in ovarian hormone exposure following bilateral prophylactic oophorectomy (i.e., surgical removal of the ovaries) may...

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PMID: 10469748
DOI: 10.1093/jnci/91.17.1475

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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