Article
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers.
Journal of the National Cancer Institute - 7 Nov 2001
Hartmann L C, Sellers T A, Schaid D J, Frank T S, Soderberg C L, Sitta D L, Frost M H, Grant C S, Donohue J H, Woods J E, McDonnell S K, Vockley C W, Deffenbaugh A, Couch F J, Jenkins R B
Abstract excerpt
BACKGROUND: In women with a family history of breast cancer, bilateral prophylactic mastectomy is associated with a decreased risk of subsequent breast cancer of approximately 90%. We examined the association between bilateral prophylactic mastectomy and breast cancer risk in women at high risk for breast cancer who also had mutations in BRCA1 and BRCA2 genes. METHODS: We obtained blood samples from 176 of the...
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