Article
Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation.
The New England journal of medicine - 19 Jul 2001
Meijers-Heijboer H, van Geel B, van Putten W L, Henzen-Logmans S C, Seynaeve C, Menke-Pluymers M B, Bartels C C, Verhoog L C, van den Ouweland A M, Niermeijer M F, Brekelmans C T, Klijn J G
Abstract excerpt
BACKGROUND: Women with a BRCA1 or BRCA2 mutation have a high risk of breast cancer and may choose to undergo prophylactic bilateral total mastectomy. We investigated the efficacy of this procedure in such women. METHODS: We conducted a prospective study of 139 women with a pathogenic BRCA1 or BRCA2 mutation who were enrolled in a breast-cancer surveillance program at the Rotterdam Family Cancer Clinic. At the...
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