Article
Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Journal of the National Cancer Institute - 1 Jan 2017
Kotsopoulos Joanne, Huzarski Tomasz, Gronwald Jacek, Singer Christian F, Moller Pal, Lynch Henry T, Armel Susan, Karlan Beth, Foulkes William D, Neuhausen Susan L, Senter Leigha, Tung Nadine, Weitzel Jeffrey N, Eisen Andrea, Metcalfe Kelly, Eng Charis, Pal Tuya, Evans Gareth, Sun Ping, Lubinski Jan, Narod Steven A
Abstract excerpt
Background: Whether oophorectomy reduces breast cancer risk among BRCA mutation carriers is a matter of debate. We undertook a prospective analysis of bilateral oophorectomy and breast cancer risk in BRCA mutation carriers. Methods: Subjects had no history of cancer, had both breasts intact, and had information on oophorectomy status (n = 3722). Women were followed until breast cancer diagnosis, prophylactic...
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