Article
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2004
Yoo Seung-Hee, Yamazaki Shin, Lowrey Phillip L, Shimomura Kazuhiro, Ko Caroline H, Buhr Ethan D, Siepka Sandra M, Hong Hee-Kyung, Oh Won Jun, Yoo Ook Joon, Menaker Michael, Takahashi Joseph S
Abstract excerpt
Mammalian circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), and current dogma holds that the SCN is required for the expression of circadian rhythms in peripheral tissues. Using a PERIOD2::LUCIFERASE fusion protein as a real-time reporter of circadian dynamics in mice, we report that, contrary to previous work, peripheral tissues are capable of self-sustained circadian oscillations for >20...
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