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Article

Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine

1 Jan 2014

Abstract excerpt

Disruption of circadian rhythms is a risk factor for several human gastrointestinal (GI) diseases, ranging from diarrhea to ulcers to cancer. Four-dimensional tissue culture models that faithfully mimic the circadian clock of the GI epithelium would provide an invaluable tool to understand circadian regulation of GI health and disease. We hypothesized that rhythmicity of a key circadian component, PERIOD2 (PER2),...

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PMID: 24997189
DOI: 10.1242/dmm.014399

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