Article
Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms.
Neuron - 1 Feb 2000
Field M D, Maywood E S, O'Brien J A, Weaver D R, Reppert S M, Hastings M H
Abstract excerpt
The circadian clock in the suprachiasmatic nuclei (SCN) is comprised of a cell-autonomous, autoregulatory transcriptional/translational feedback loop. Its molecular components include three period and two cryptochrome genes. We describe circadian patterns of expression of mPER2 and mPER3 in the mouse SCN that are synchronous to those for mPER1, mCRY1, and mCRY2. Coimmunoprecipitation experiments demonstrate in...
Topics
- Animals
- Cell Cycle Proteins
- Circadian Rhythm
- Cryptochromes
- Drosophila
- Drosophila Proteins
- Eye Proteins
- Flavoproteins
- Gene Expression
- Genetic Variation
- In Situ Hybridization
- Male
- Mice
- Mice, Inbred Strains