Article
Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light, and dynamics of Per1 and Per2 gene expression under long and short photoperiods.
Journal of biological rhythms - 1 Jun 2002
Steinlechner Stephan, Jacobmeier Birgit, Scherbarth Frank, Dernbach Haiko, Kruse Friederike, Albrecht Urs
Abstract excerpt
The Per1 and Per2 genes are components of the mammalian circadian clock. Mutations in these genes alter phase resetting in response to a nocturnal light pulse, and Per2 mutant mice are known to become arrhythmic in constant darkness. We show that under constant light conditions, Per2 mutant mice exhibit robust activity rhythms as well as body temperature rhythms with a period length that is less than 24 h. In...
Topics
- Animals
- Body Temperature
- Cell Cycle Proteins
- Circadian Rhythm
- Gene Expression
- Light
- Mice
- Mice, Mutant Strains
- Mutation
- Nuclear Proteins
- Period Circadian Proteins