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Article

Epigenetic inheritance of circadian period in clonal cells.

eLife - 27 May 2020

Li Yan, Shan Yongli, Kilaru Gokhul Krishna, Berto Stefano, Wang Guang-Zhong, Cox Kimberly H, Yoo Seung-Hee, Yang Shuzhang, Konopka Genevieve, Takahashi Joseph S

Abstract excerpt

Circadian oscillations are generated via transcriptional-translational negative feedback loops. However, individual cells from fibroblast cell lines have heterogeneous rhythms, oscillating independently and with different period lengths. Here we showed that heterogeneity in circadian period is heritable and used a multi-omics approach to investigate underlying mechanisms. By examining large-scale...

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Identifiers

PMID: 32459177
DOI: 10.7554/eLife.54186
PMCID: PMC7289596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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