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Article

Negative effect of genetic bottlenecks on the adaptability of vesicular stomatitis virus.

Journal of molecular biology - 6 Feb 2004

Novella I S

Abstract excerpt

Muller's ratchet is a principle of evolutionary genetics describing mutant accumulation in populations that are repeatedly subjected to genetic bottleneck. The immediate effect of Muller's ratchet, overall loss of fitness, has been confirmed in several viral systems belonging to different groups. This report shows that in addition to fitness loss, genetic bottlenecks also have longer-term effects, namely changes...

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Identifiers

PMID: 14741203
DOI: 10.1016/j.jmb.2003.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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