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Article

Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events.

Journal of virology - 1 Apr 1999

Yuste E, Sánchez-Palomino S, Casado C, Domingo E, López-Galíndez C

Abstract excerpt

Muller's ratchet predicts fitness losses in small populations of asexual organisms because of the irreversible accumulation of deleterious mutations and genetic drift. This effect should be enhanced if population bottlenecks intervene and fixation of mutations is not compensated by recombination. To study whether Muller's ratchet could operate in a retrovirus, 10 biological clones were derived from a human...

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Identifiers

PMID: 10074121
DOI: 10.1128/JVI.73.4.2745-2751.1999
PMCID: PMC104031

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