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Article

Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness.

Journal of virology - 1 May 1995

Novella I S, Elena S F, Moya A, Domingo E, Holland J J

Abstract excerpt

Genetic bottlenecks are important events in the genetic diversification of organisms and colonization of new ecological niches. Repeated bottlenecking of RNA viruses often leads to fitness losses due to the operation of Muller's ratchet. Herein we use vesicular stomatitis virus to determine the transmission population size which leads to fitness decreases of virus populations. Remarkably, the effective size of a...

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Identifiers

PMID: 7707510
DOI: 10.1128/JVI.69.5.2869-2872.1995
PMCID: PMC188983

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