Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness.

doi:10.1128/JVI.69.5.2869-2872.1995

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Article

Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness.

Journal of virology - 1 May 1995

Novella I S, Elena S F, Moya A, Domingo E, Holland J J

Abstract excerpt

Genetic bottlenecks are important events in the genetic diversification of organisms and colonization of new ecological niches. Repeated bottlenecking of RNA viruses often leads to fitness losses due to the operation of Muller's ratchet. Herein we use vesicular stomatitis virus to determine the t...

Topics

Animals
Biological Evolution
Cell Line
Cricetinae
Ecosystem
Founder Effect
Genetic Variation
Mutation
Selection, Genetic
Vesicular stomatitis Indiana virus
Virus Replication

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