Article
High mutation rates, bottlenecks, and robustness of RNA viral quasispecies.
Gene - 14 Mar 2005
Manrubia Susanna C, Escarmís Cristina, Domingo Esteban, Lázaro Ester
Abstract excerpt
Population bottlenecks are stochastic events that strongly condition the structure and evolution of natural populations. Their effects are readily observable in highly heterogeneous populations, such as RNA viruses, since bottlenecks cause a fast accumulation of mutations. Considering that most mutations are deleterious, it was predicted that the frequent application of bottlenecks would yield a population unable...
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