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Article

Molecular basis of fitness loss and fitness recovery in vesicular stomatitis virus.

Journal of molecular biology - 1 Oct 2004

Novella I S, Ebendick-Corpus B E

Abstract excerpt

Viral populations subjected to repeated genetic bottleneck accumulate deleterious mutations in a process known as Muller's ratchet. Asexual viruses, such as vesicular stomatitis virus (VSV) can recover from Muller's ratchet by replication with large effective population sizes. However, mutants with a history of bottleneck transmissions often show decreased adaptability when compared to non-bottlenecked...

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Identifiers

PMID: 15364571
DOI: 10.1016/j.jmb.2004.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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