Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.

doi:10.1128/JVI.67.6.3620-3623.1993

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Article

Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.

Journal of virology - 1 Jun 1993

Duarte E A, Clarke D K, Moya A, Elena S F, Domingo E, Holland J

Abstract excerpt

We showed earlier that transfers of large populations of RNA viruses lead to fitness gains and that repeated genetic bottleneck transfers result in fitness losses due to Muller's ratchet. In the present study, we examined the effects of genetic bottleneck passages intervening between population p...

Topics

Genetic Variation
Selection, Genetic
Serial Passage
Vesicular stomatitis Indiana virus
Virus Replication

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