Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of Muller's ratchet in herpes simplex virus type 1.

The Journal of general virology - 1 Feb 2013

Jaramillo Nacarí, Domingo Esteban, Muñoz-Egea María Carmen, Tabarés Enrique, Gadea Ignacio

Abstract excerpt

Population bottlenecks can have major effects in the evolution of RNA viruses, but their possible influence in the evolution of DNA viruses is largely unknown. Genetic and biological variation of herpes simplex virus type 1 (HSV-1) has been studied by subjecting 23 biological clones of the virus to 10 plaque-to-plaque transfers. In contrast to large population passages, plaque transfers led to a decrease in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to Herpes Simplex
Share to Herpesvirus 1, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lethal Dose 50

Share to Mutation Rate

Share to Serial Passage

Share to Survival Analysis

Share to Viral Proteins

Source

Identifiers

PMID: 23100362
DOI: 10.1099/vir.0.044685-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of Muller's ratchet in herpes simplex virus type 1.PMID 23100362Read ↗

Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet.Semantic proximity Read ↗

Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events.Semantic proximity Read ↗

Genetic lesions associated with Muller's ratchet in an RNA virus.Semantic proximity Read ↗

Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.Semantic proximity Read ↗

<i>In vitro</i> evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in Vero cell cultureSemantic proximity Read ↗

Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction.Semantic proximity Read ↗

Negative effect of genetic bottlenecks on the adaptability of vesicular stomatitis virus.Semantic proximity Read ↗

Basic concepts in RNA virus evolution.Semantic proximity Read ↗

Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.Semantic proximity Read ↗

In vitro evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in cell cultureSemantic proximity Read ↗

Resistance to extinction of low fitness virus subjected to plaque-to-plaque transfers: diversification by mutation clustering.Semantic proximity Read ↗

Quasispecies dynamics and RNA virus extinction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.