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Article

Mutational effects and population dynamics during viral adaptation challenge current models.

Genetics - 1 Jan 2011

Miller Craig R, Joyce Paul, Wichman Holly A

Abstract excerpt

Adaptation in haploid organisms has been extensively modeled but little tested. Using a microvirid bacteriophage (ID11), we conducted serial passage adaptations at two bottleneck sizes (10(4) and 10(6)), followed by fitness assays and whole-genome sequencing of 631 individual isolates. Extensive genetic variation was observed including 22 beneficial, several nearly neutral, and several deleterious mutations. In...

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Identifiers

PMID: 21041559
DOI: 10.1534/genetics.110.121400
PMCID: PMC3018297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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