Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet.

doi:10.1073/pnas.89.13.6015

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Article

Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1992

Duarte E, Clarke D, Moya A, Domingo E, Holland J

Abstract excerpt

Muller's ratchet is an important concept in population genetics. It predicts that when mutation rates are high and a significant proportion of mutations are deleterious, a kind of irreversible ratchet mechanism will gradually decrease the mean fitness of small populations of asexual organisms. In...

Topics

Animals
Cells, Cultured
Cricetinae
Genetics, Population
HeLa Cells
Humans
In Vitro Techniques
Mutation
RNA Viruses
Vesicular stomatitis Indiana virus
Virus Replication

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