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Article

Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1992

Duarte E, Clarke D, Moya A, Domingo E, Holland J

Abstract excerpt

Muller's ratchet is an important concept in population genetics. It predicts that when mutation rates are high and a significant proportion of mutations are deleterious, a kind of irreversible ratchet mechanism will gradually decrease the mean fitness of small populations of asexual organisms. In contrast, sexual recombination may stop or reverse this mutational ratchet by recombinational repair of genetic...

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Identifiers

PMID: 1321432
DOI: 10.1073/pnas.89.13.6015
PMCID: PMC402129

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