Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.

doi:10.1128/JVI.67.1.222-228.1993

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Article

Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.

Journal of virology - 1 Jan 1993

Clarke D K, Duarte E A, Moya A, Elena S F, Domingo E, Holland J

Abstract excerpt

Repeated clone-to-clone (genetic bottleneck) passages of an RNA phage and vesicular stomatitis virus have been shown previously to result in loss of fitness due to Muller's ratchet. We now demonstrate that Muller's ratchet also operates when genetic bottleneck passages are carried out at 37 rathe...

Topics

Cell Line
Genetic Variation
Genome, Viral
Hot Temperature
Mutagenesis
RNA Viruses
Selection, Genetic
Serial Passage
Time Factors
Vesicular stomatitis Indiana virus

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