Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.

Journal of virology - 1 Jan 1993

Clarke D K, Duarte E A, Moya A, Elena S F, Domingo E, Holland J

Abstract excerpt

Repeated clone-to-clone (genetic bottleneck) passages of an RNA phage and vesicular stomatitis virus have been shown previously to result in loss of fitness due to Muller's ratchet. We now demonstrate that Muller's ratchet also operates when genetic bottleneck passages are carried out at 37 rather than 32 degrees C. Thus, these fitness losses do not depend on growth of temperature-sensitive (ts) mutants at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Serial Passage
Share to Cell Line
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Hot Temperature

Share to Mutagenesis

Share to Selection, Genetic

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 8380072
DOI: 10.1128/JVI.67.1.222-228.1993
PMCID: PMC237355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.PMID 8380072Read ↗

Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet.Semantic proximity Read ↗

Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.Semantic proximity Read ↗

Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness.Semantic proximity Read ↗

Subclonal components of consensus fitness in an RNA virus clone.Semantic proximity Read ↗

Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events.Semantic proximity Read ↗

Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet.Semantic proximity Read ↗

Negative effect of genetic bottlenecks on the adaptability of vesicular stomatitis virus.Semantic proximity Read ↗

Genetic lesions associated with Muller's ratchet in an RNA virus.Semantic proximity Read ↗

The two faces of mutation: extinction and adaptation in RNA viruses.Semantic proximity Read ↗

Molecular basis of fitness loss and fitness recovery in vesicular stomatitis virus.Semantic proximity Read ↗

Fitness declines in Tobacco etch virus upon serial bottleneck transfers.Semantic proximity Read ↗

Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.