Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 1999

Bergstrom C T, McElhany P, Real L A

Abstract excerpt

Transmission bottlenecks occur in pathogen populations when only a few individual pathogens are transmitted from one infected host to another in the initiation of a new infection. Transmission bottlenecks can dramatically affect the evolution of virulence in rapidly evolving pathogens such as RNA viruses. Characterizing pathogen diversity with the quasispecies concept, we use analytical and simulation methods to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to RNA Viruses

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 10220424
DOI: 10.1073/pnas.96.9.5095
PMCID: PMC21822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens.PMID 10220424Read ↗

The impact of bottlenecks on microbial survival, adaptation, and phenotypic switching in host-pathogen interactions.Semantic proximity Read ↗

Two optimal mutation rates in obligate pathogens subject to deleterious mutation.Semantic proximity Read ↗

Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses.Semantic proximity Read ↗

Effects of Transmission Bottlenecks on the Diversity of Influenza A Virus.Semantic proximity Read ↗

Cross-scale dynamics and the evolutionary emergence of infectious diseasesSemantic proximity Read ↗

Why are viral genomes so fragile? The bottleneck hypothesis.Semantic proximity Read ↗

Pathogen population bottlenecks and adaptive landscapes: overcoming the barriers to disease emergence.Semantic proximity Read ↗

Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet.Semantic proximity Read ↗

Quasispecies theory and the behavior of RNA viruses.Semantic proximity Read ↗

High mutation rates, bottlenecks, and robustness of RNA viral quasispecies.Semantic proximity Read ↗

Transmission cycles generate diversity in pathogenic virusesSemantic proximity Read ↗

Unifying the epidemiological and evolutionary dynamics of pathogens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.