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Article

Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2001

Elena S F, Sanjuán R, Bordería A V, Turner P E

Abstract excerpt

We explored the evolutionary importance of two factors in the adaptation of RNA viruses to their cellular hosts, size of viral inoculum used to initiate a new infection, and mode of transmission (horizontal versus vertical). Transmission bottlenecks should occur in natural populations of viruses and their profound effects on viral adaptation have been previously documented. However, the role of transmission mode...

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Identifiers

PMID: 12798049
DOI: 10.1016/s1567-1348(01)00006-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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