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Article

A recombinant model for assessing the role of GSTM1 in styrene-7,8-oxide toxicity and mutagenicity.

Toxicology - 15 Jan 2004

Shield Alison J, Sanderson Barbara J S

Abstract excerpt

Styrene-7,8-oxide (SO) is a highly reactive epoxide able to undergo reactions with endogenous nucleophiles, such as DNA. SO is inactivated by glutathione-S-transferase M1 (GSTM1). This detoxification enzyme is absent in approximately one-half of Caucasian (49%) populations. A GSTM1 recombinant human lymphoblastoid cell line (FB7) was generated from a GSTM1 negative parental cell line (WIL2NS). GSTM1 status was...

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Source

Identifiers

PMID: 14698568
DOI: 10.1016/j.tox.2003.08.010

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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