Stable heterologous expression of hydroxysteroid sulphotransferase in Chinese hamster V79 cells and their use for toxicological investigations.

doi:10.1016/0009-2797(94)90058-2

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Article

Stable heterologous expression of hydroxysteroid sulphotransferase in Chinese hamster V79 cells and their use for toxicological investigations.

Chemico-biological interactions - 1 Jun 1994

Czich A, Bartsch I, Dogra S, Hornhardt S, Glatt H R

Abstract excerpt

Various benzylic alcohols are metabolically activated to electrophilic, potentially mutagenic and carcinogenic sulphuric acid esters. The involved sulphotransferases are not expressed in the cell lines in culture which are commonly used for mutagenicity testing. The liver of adult female rats is...

Topics

Animals
Anthracenes
Benzopyrenes
Biotransformation
Cell Line
Cloning, Molecular
Cricetinae
Cricetulus
DNA, Complementary
Female
Liver
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Mutation

Pyrenes

Rats

Sister Chromatid Exchange

Sulfotransferases

Source

Open in PubMed

Identifiers

PMID: 8033247
DOI: 10.1016/0009-2797(94)90058-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8033247-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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