Article
Influence of DNA repair on nonlinear dose-responses for mutation.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2013
Thomas Adam D, Jenkins Gareth J S, Kaina Bernd, Bodger Owen G, Tomaszowski Karl-Heinz, Lewis Paul D, Doak Shareen H, Johnson George E
Abstract excerpt
Recent evidence has challenged the default assumption that all DNA-reactive alkylating agents exhibit a linear dose-response. Emerging evidence suggests that the model alkylating agents methyl- and ethylmethanesulfonate and methylnitrosourea (MNU) and ethylnitrosourea observe a nonlinear dose-response with a no observed genotoxic effect level (NOGEL). Follow-up mechanistic studies are essential to understand the...
Topics
- Base Sequence
- Cell Line
- DNA Modification Methylases
- DNA Primers
- DNA Repair
- DNA Repair Enzymes
- Dose-Response Relationship, Drug
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutagens
- Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Proteins