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Article

Influence of DNA repair on nonlinear dose-responses for mutation.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2013

Thomas Adam D, Jenkins Gareth J S, Kaina Bernd, Bodger Owen G, Tomaszowski Karl-Heinz, Lewis Paul D, Doak Shareen H, Johnson George E

Abstract excerpt

Recent evidence has challenged the default assumption that all DNA-reactive alkylating agents exhibit a linear dose-response. Emerging evidence suggests that the model alkylating agents methyl- and ethylmethanesulfonate and methylnitrosourea (MNU) and ethylnitrosourea observe a nonlinear dose-response with a no observed genotoxic effect level (NOGEL). Follow-up mechanistic studies are essential to understand the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23288051
DOI: 10.1093/toxsci/kfs341
PMCID: PMC3576011

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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