Article
The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals.
Mutagenesis - 1 Sept 1995
Combes R D, Stopper H, Caspary W J
Abstract excerpt
Guidelines have been proposed to assess the potential of chemicals to affect human health. Written into these guidelines is the requirement that information be submitted on mutagenic activity. Although regulatory agencies accept mutagenicity data from both the hprt and tk loci in mammalian cells,...
Topics
- Aneuploidy
- Animals
- Cell Count
- Cell Size
- Chromosome Aberrations
- Chromosomes
- Drug Resistance
- Guidelines as Topic
- Leukemia L5178
- Mice
- Micronucleus Tests
- Mutagenicity Tests
- Mutation
- Thymidine Kinase
- Trifluridine
- Tumor Cells, Cultured
- Tumor Stem Cell Assay
- United States